CNUP Training Faculty

Kenneth N. Fish, Ph.D.

Assistant Professor, Psychiatry

Ph.D. Oregon Health and Science University (1998)

Office: E1652 Biomedical Science Tower
Telephone:412-648-9366
Fax:412-624-9910
E-mail: fishkn@upmc.edu
Website: http://www.tnp.pitt.edu

Functional consequences of altered connectivity in schizophrenia; the early secretory pathway’s role in neurodevelopment and synaptogenesis

Research Summary:

Dr. Fish and his colleagues are interested in two different, but converging research areas: (1) identifying how key cells, potential pharmacological targets, involved in GABA neurotransmission are affected in schizophrenia; (2) defining the functional role of the early secretory pathway in neuronal polarity, development, and synaptogenesis. Studies utilize primary cells/tissue and advanced microscopy methodologies.

Selected Publications:

Aridor, M. and Fish, K.N. Selective targeting of ER exit sites supports axon development. Traffic. In press.

Fish, K.N., Sweet, R.A., Deo, A.J. and Lewis, D.A. An automated segmentation methodology for quantifying immunoreactive puncta number and fluorescence intensity in tissue sections. Brain Res. 1240:62-72, 2008.

Fish, K.N. and Krucker, T. Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse. Neurobiol. Dis. 32:391-401, 2008.

Barr, A.M., Fish, K.N., Markou, A. and Honer, W. Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins. Euro J Neurosci. 27(10): 2568-2574, 2008.

Maclaurin, S.A., Krucker, T. and Fish, K.N. Hippocampal dendritic arbor growth in vitro: Regulation by reelin-disabled-1 signaling. Brain Res 1172:1-9, 2007.

Aridor, M., Guzik, A.K., Bielli, A. and Fish, K.N. Endoplasmic reticulum export site formation and function in dendrites. J Neurosci 24(15):3770-3776, 2004.