CNUP Training Faculty

C. Edward Dixon, Ph.D.

Professor, Neurological Surgery, Anesthesiology, Neurobiology, Physical Medicine & Rehabilitation

Ph.D. Virginia Commonwealth University (1985)

Office: 217 Hill Building
Telephone:412-383-2188
Fax:412-624-0943
E-mail: dixoec@upmc.edu
Website:

Mechanisms of post-traumatic memory deficits, models of traumatic brain injury, and functional outcomes.

Research Summary:

Mechanisms of induction and recovery of functional deficits following traumatic brain injury; neurotransmitter agonist therapies for recovery of post traumatic functional deficits; models of traumatic brain injury; clinical studies of pharmacotherapy in TBI patients.

Selected Publications:

Yan, H.Q., Ma, X., Chen, X., Li, Y., Shao, L. and Dixon, C.E. Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury. Brain Res 1134: 171-179, 2007.

Clark, R.S.B., Nathaniel, P.D., Zhang, X., Dixon, C.E., Alber, S.M., Watkins, S.C., Melick, J.A., Kochanek, P.M. and Graham, S.H. boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats. J Cereb Blood Flow Metab 27: 316-326, 2007.

Kline, A.E., Massucci, J.L., Zafonte, R.D., Dixon, C.E., Defeo, J.R. and Rogers, E.H. Differential effects of single versus multiple administrations of haloperidol and risperidone on functional outcome after experimental brain trauma. Crit Care Med 35(3): 919-924, 2007.

Wagner, A.K., Ren, D., Conley, Y.P., Ma, X., Kerr, M.E., Zafonte, R.D., Puccio, A.M., Marion, D.W. and Dixon, C.E. Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury. J Neurosurg 106: 538-547, 2007.

Clark, R., Vagni, V., Nathaniel, P., Jenkins, L., Dixon, C.E. and Szabo, C. Local administration of the poly-ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice. J Neurotrauma 2007 (in press).